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Call for Paper
The International Journal of Biophotonics and Biomedical Engineering (IJBBE) of the Islamic Azad University, Tabriz Branch, invites manuscript submissions. The emerging fields of Biomedical Engineering and Biophotonics has opened up new horizons for considerably extensive transfer of applicable state–of–art technology, related to the electronics, laser and electro-optics to the life sciences and medicine. For the past two decades, the new innovations in the area of biophotonic technologies impose significant impact on biomedical research and public health, due to minimally invasive advances, cost-effective and rapid techniques for precise diagnostics, monitoring, and treatment of a variety of diseases. The purpose of this journal is to highlight the recent progress, and trends in development of leading edge technologies in biomedical Engineering and biophotonics.
Recent Articles
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Open Access Article
1 - Investigation of skin toxicity in breast cancer patients undergoing radiation therapy
Mohammad Bayatzadeh Sharifeh ShahiIssue 2 , Vol. 3 , Autumn 2024This study investigated skin toxicity in breast cancer patients undergoing radiation therapy. The study was conducted in 1401 at a radiation therapy center in Yazd city and included 30 patients who underwent radiation therapy using conventional and hypofractionation met MoreThis study investigated skin toxicity in breast cancer patients undergoing radiation therapy. The study was conducted in 1401 at a radiation therapy center in Yazd city and included 30 patients who underwent radiation therapy using conventional and hypofractionation methods, and in which the whole or part of the breast was exposed to radiation. Skin complications of grade skin toxicity during treatment and within 40 days after radiotherapy were evaluated in both methods. Results showed that the four people (26.6%) had grade three and the six people (40.0%) had grade two skin toxicity, with conventional treatment causing more skin complications compared to hypofractionation, which caused fewer skin complications without reducing efficacy. Additionally, the ratio of skin complications in the conventional technique was higher than in the hypofractionation technique after 40 days of radiation therapy. The study concluded that hypofractionation results in fewer skin complications than conventional treatment. Manuscript profile -
Open Access Article
2 - Simulation of surface flux received through breast tumor radiation therapy with MCNPX code
Parsa Afshin Sharifeh Shahi Farhad Azimi FarIssue 2 , Vol. 3 , Autumn 2024In radiation therapy, investigating of the effects of the surface flux reaching on the tissue is important in planning the treatment and this requires a precise evaluation of the absorbed dose distribution throughout the irradiated tissue. Therefore, by Monte Carlo simu MoreIn radiation therapy, investigating of the effects of the surface flux reaching on the tissue is important in planning the treatment and this requires a precise evaluation of the absorbed dose distribution throughout the irradiated tissue. Therefore, by Monte Carlo simulation with MCNP code, a point source with the size of E with a spectrum width of 0.6 µm with a single energy transfer of 6 MeV to the breast tumor tissue with a size of 2 x 4 x 4 cm and also a density (Kg/m^3) of 11.34 at a fixed depth of 3 cm. It is radiated from a standard phantom (VIP MAN) made of tissue. The results show the highest surface flux that received on the tumor is around 9.97 × 〖10〗^(-6) and is located almost in the center of the tumor in dimensions (-0.75 cm - 1.3 cm) and the less surface flux around the tumor is caused by the rate of the dose which is distributed. Also, the template phenomenon in the creation of electrons is based on the Compton effect, while in the creation of photons, the Compton effect did not occur. Manuscript profile -
Open Access Article
3 - Photocatalytic removal of ceftriaxone from aqueous solutions using g-C3N4
Parvin GharbaniIssue 2 , Vol. 3 , Autumn 2024Ceftriaxone is a one of Pharmaceutical compounds that cause pollution of water. In this research, g-C3N4 photocatalyst was synthesized and its efficiency in removal of ceftriaxone was studied. The synthesized g-C3N4 was analyzed using XRD, FTIR, FESEM,EDS and dot mappin MoreCeftriaxone is a one of Pharmaceutical compounds that cause pollution of water. In this research, g-C3N4 photocatalyst was synthesized and its efficiency in removal of ceftriaxone was studied. The synthesized g-C3N4 was analyzed using XRD, FTIR, FESEM,EDS and dot mapping. The effect of initial concentration of ceftriaxone, dosage of photocatalyst, irradiation time and pH was studied and based on these results, the highest removal efficiency of ceftriaxone from water was obtained about 83.4% at the concentration of 20 mg/L, pH=2 , 0.25 g/500 mL of g-C3N4 photocatalyst at 50 min of irradiation time. This study confirmed that g-C3N4 photocatalyst can be efficiently removed of ceftriaxone from water. Manuscript profile -
Open Access Article
4 - Detection of the blood hemoglobin using an electro-optical biosensor based on a structurally chiral medium
Amir Madani Nadia Ghorani Samad Roshan EntezarIssue 2 , Vol. 3 , Autumn 2024In this work, a biosensor based on a structurally chiral medium (SCM) under the effect of a low-frequency electric field has been designed to detect blood hemoglobin. The introduced structure is irradiated with a circularly polarized light under an electro-optical Pocke MoreIn this work, a biosensor based on a structurally chiral medium (SCM) under the effect of a low-frequency electric field has been designed to detect blood hemoglobin. The introduced structure is irradiated with a circularly polarized light under an electro-optical Pockels effect. A photonic band gap is observed in the transmission spectrum of the right-handed circularly polarized waves, which indicates the circular Bragg phenomenon. The sensor consists of a sample layer sandwiched between two identical SCMs. Sensor performance is evaluated using the transfer matrix method (TMM). The results show that the defect mode is sensitive to any change in the refractive index of the defect layer where the defect layer is infiltrated with samples with different concentrations of blood hemoglobin. Also, it is shown that applying a low-frequency electric field increases the sensitivity of the mentioned sensor. It is observed that the sensitivity can be expanded up to 142.66 nm/RIU by changing the various parameters of the SCM. Manuscript profile -
Open Access Article
5 - Fluence and wavelength optimization of pulsed laser in photothermal therapy
Rasoul Malekfar Neda AmjadiIssue 2 , Vol. 3 , Autumn 2024The ability of Plasmonic nanoparticles (PNPs) to efficiently convert absorbed light energy into localized heat has made them a popular choice for photothermal medical applications. However, during the photothermal process, the diffusion of localized heat can lead to tem MoreThe ability of Plasmonic nanoparticles (PNPs) to efficiently convert absorbed light energy into localized heat has made them a popular choice for photothermal medical applications. However, during the photothermal process, the diffusion of localized heat can lead to temperature management challenges. To address this issue, researchers have developed a new generation of PNPs incorporating optical phase transition materials, allowing for tunable photothermal responses without altering the geometry. This tunability is achieved through rapid changes in optical and thermal properties during phase transitions. In this study, we conducted a numerical analysis on the photothermal response of a VO2@Au smart nanoshell in both tumor and healthy liver tissue under irradiation with a nanosecond (5 ns) pulsed laser. To obtain the temperature profile, we solved a coupling problem between electromagnetism and thermodynamics. Manuscript profile -
Open Access Article
6 - Automatic design and 3D segmentation of mandible bone using CNN algorithm via exclusive GUI
Nadia MehradKia Shakiba Mohammadi Sayedali MousaviIssue 2 , Vol. 3 , Autumn 2024Nowadays scientists are looking for decreasing dental faults by presenting new approaches.It is obvious that comprehensive information about the anatomic position of the inferior alveolar neuralcanal is essential to have the most ideal mandible surgery or systemic tooth MoreNowadays scientists are looking for decreasing dental faults by presenting new approaches.It is obvious that comprehensive information about the anatomic position of the inferior alveolar neuralcanal is essential to have the most ideal mandible surgery or systemic tooth implant. Accordingly, wepresent a new approach in this article that can be used to have 3D segmentation and recognition of thementioned canal in mandible by CBCT image. This approach includes two main steps. In the first step,we train a full convolutional 3D net (FCN) to reach the ability of section recognition, which can recognizethe relevant area of mandible bone. And in the next step, we define a 3D U-net, which is similar to FCN,to segment the inferior Alveolar neural (IAN) canal from the lower jaw. Evaluated on publicly availabledatasets, our method achieved an average Dice coefficient of 86.61%. Manuscript profile -
Open Access Article
7 - Reduced Biofilm Formation of Pseudomonas Aeruginosa by Silver Modified Iron Oxide
Davoud kabudanian Raheleh Safaei javan Shohreh Zare kariziIssue 2 , Vol. 3 , Autumn 2024Objectives and Background: Pseudomonas aeruginosa (P. aeruginosa) is a nosocomial opportunistic pathogen. Considering the importance of biofilm in pathogenicity and resistance of these bacteria, efforts should be made to find new antibacterial compounds.Methods: The Fe3 MoreObjectives and Background: Pseudomonas aeruginosa (P. aeruginosa) is a nosocomial opportunistic pathogen. Considering the importance of biofilm in pathogenicity and resistance of these bacteria, efforts should be made to find new antibacterial compounds.Methods: The Fe3O4 nanoparticles were synthesized by the co-precipitation method and were modified by the AgNO3 reductive solution to investigate influencing of Ag-Fe3O4 nanoparticles on biofilm formation of P. aeruginosa. The synthesized nanoparticles properties were determined by FESEM, DLS, FTIR, XRD and Zeta potential tests. Results: FESEM and DLS revealed the cubic and smooth structure with average size of 44.36 nm. XRD analyzes confirmed the presence of magnetite core. FTIR spectrum determined the existence of silver plating on the magnetic surface. The Zeta potential results indicated that the magnetic nanoparticle’s surface net charge was 24.4 and the surface net charge for silver modified nanoparticles was -28.3. Finally, after separating 40 isolates of P. aeruginosa among 82 clinical isolates as strong biofilm producers, then the inhibitory effect of synthesised Ag- Fe3O4 nanoparticles on the formation of biofilms was studied using the broth micro-dilution method.Conclusions: Accordingly, it was proved that Ag-Fe3O4 nanoparticles can be used to treat biofilm infections and were introduced as the new antimicrobial agents Manuscript profile
Most Viewed Articles
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Open Access Article
1 - Optical Coherence Tomography: A Brief Review
Nasser Moslehi MilaniIssue 1 , Vol. 3 , Winter 2023Optical coherence tomography (OCT) is a new imaging technique with a significant role in the field of medicine. It is a light-based non-invasive imaging method that provides high quality cross-sectional and volumetric images. OCT technology was introduced in the early 1 MoreOptical coherence tomography (OCT) is a new imaging technique with a significant role in the field of medicine. It is a light-based non-invasive imaging method that provides high quality cross-sectional and volumetric images. OCT technology was introduced in the early 1990s and advanced to produce quicker obtaining times and higher resolution. In this article we discuss some of the recent advancements in OCT imaging systems. We will review a brief history and first operating principles including light coherence interferometry (LCI), time domain optical coherence tomography (TD-OCT) and Fourier domain optical coherence tomography (FD-OCT) contains two types: spectral domain optical coherence tomography (SD-OCT) and swept source optical coherence tomography (SS-OCT). Also we review recent emerging innovative OCT systems including Doppler OCT, polarization sensitive optical coherence tomography (PS-OCT), high resolution optical coherence tomography (HR-OCT), full field optical coherence tomography (FF-OCT), wide field optical coherence tomography (WF-OCT), optical coherence elastography (OCE), adaptive optics optical coherence tomography (AO-OCT), visible light optical coherence tomography (Vis-OCT), intraoperative optical coherence tomography (iOCT), hand-held optical coherence tomography (HH-OCT), and OCT in needle format. Manuscript profile -
Open Access Article
2 - Photocatalytic removal of ceftriaxone from aqueous solutions using g-C3N4
Parvin GharbaniIssue 2 , Vol. 3 , Autumn 2024Ceftriaxone is a one of Pharmaceutical compounds that cause pollution of water. In this research, g-C3N4 photocatalyst was synthesized and its efficiency in removal of ceftriaxone was studied. The synthesized g-C3N4 was analyzed using XRD, FTIR, FESEM,EDS and dot mappin MoreCeftriaxone is a one of Pharmaceutical compounds that cause pollution of water. In this research, g-C3N4 photocatalyst was synthesized and its efficiency in removal of ceftriaxone was studied. The synthesized g-C3N4 was analyzed using XRD, FTIR, FESEM,EDS and dot mapping. The effect of initial concentration of ceftriaxone, dosage of photocatalyst, irradiation time and pH was studied and based on these results, the highest removal efficiency of ceftriaxone from water was obtained about 83.4% at the concentration of 20 mg/L, pH=2 , 0.25 g/500 mL of g-C3N4 photocatalyst at 50 min of irradiation time. This study confirmed that g-C3N4 photocatalyst can be efficiently removed of ceftriaxone from water. Manuscript profile -
Open Access Article
3 - Detection of the blood hemoglobin using an electro-optical biosensor based on a structurally chiral medium
Amir Madani Nadia Ghorani Samad Roshan EntezarIssue 2 , Vol. 3 , Autumn 2024In this work, a biosensor based on a structurally chiral medium (SCM) under the effect of a low-frequency electric field has been designed to detect blood hemoglobin. The introduced structure is irradiated with a circularly polarized light under an electro-optical Pocke MoreIn this work, a biosensor based on a structurally chiral medium (SCM) under the effect of a low-frequency electric field has been designed to detect blood hemoglobin. The introduced structure is irradiated with a circularly polarized light under an electro-optical Pockels effect. A photonic band gap is observed in the transmission spectrum of the right-handed circularly polarized waves, which indicates the circular Bragg phenomenon. The sensor consists of a sample layer sandwiched between two identical SCMs. Sensor performance is evaluated using the transfer matrix method (TMM). The results show that the defect mode is sensitive to any change in the refractive index of the defect layer where the defect layer is infiltrated with samples with different concentrations of blood hemoglobin. Also, it is shown that applying a low-frequency electric field increases the sensitivity of the mentioned sensor. It is observed that the sensitivity can be expanded up to 142.66 nm/RIU by changing the various parameters of the SCM. Manuscript profile -
Open Access Article
4 - Simulation of surface flux received through breast tumor radiation therapy with MCNPX code
Parsa Afshin Sharifeh Shahi Farhad Azimi FarIssue 2 , Vol. 3 , Autumn 2024In radiation therapy, investigating of the effects of the surface flux reaching on the tissue is important in planning the treatment and this requires a precise evaluation of the absorbed dose distribution throughout the irradiated tissue. Therefore, by Monte Carlo simu MoreIn radiation therapy, investigating of the effects of the surface flux reaching on the tissue is important in planning the treatment and this requires a precise evaluation of the absorbed dose distribution throughout the irradiated tissue. Therefore, by Monte Carlo simulation with MCNP code, a point source with the size of E with a spectrum width of 0.6 µm with a single energy transfer of 6 MeV to the breast tumor tissue with a size of 2 x 4 x 4 cm and also a density (Kg/m^3) of 11.34 at a fixed depth of 3 cm. It is radiated from a standard phantom (VIP MAN) made of tissue. The results show the highest surface flux that received on the tumor is around 9.97 × 〖10〗^(-6) and is located almost in the center of the tumor in dimensions (-0.75 cm - 1.3 cm) and the less surface flux around the tumor is caused by the rate of the dose which is distributed. Also, the template phenomenon in the creation of electrons is based on the Compton effect, while in the creation of photons, the Compton effect did not occur. Manuscript profile -
Open Access Article
5 - Automatic design and 3D segmentation of mandible bone using CNN algorithm via exclusive GUI
Nadia MehradKia Shakiba Mohammadi Sayedali MousaviIssue 2 , Vol. 3 , Autumn 2024Nowadays scientists are looking for decreasing dental faults by presenting new approaches.It is obvious that comprehensive information about the anatomic position of the inferior alveolar neuralcanal is essential to have the most ideal mandible surgery or systemic tooth MoreNowadays scientists are looking for decreasing dental faults by presenting new approaches.It is obvious that comprehensive information about the anatomic position of the inferior alveolar neuralcanal is essential to have the most ideal mandible surgery or systemic tooth implant. Accordingly, wepresent a new approach in this article that can be used to have 3D segmentation and recognition of thementioned canal in mandible by CBCT image. This approach includes two main steps. In the first step,we train a full convolutional 3D net (FCN) to reach the ability of section recognition, which can recognizethe relevant area of mandible bone. And in the next step, we define a 3D U-net, which is similar to FCN,to segment the inferior Alveolar neural (IAN) canal from the lower jaw. Evaluated on publicly availabledatasets, our method achieved an average Dice coefficient of 86.61%. Manuscript profile -
Open Access Article
6 - Designing real-time biosensors and chemical sensors based on symmetrical photonic crystal heterostructures
maryam sharifi Habib Tajalli Hamid Pashaei Adl Payman TajalliIssue 1 , Vol. 1 , Winter 2021In this paper, we introduce and analytically demonstrate a novel biosensor based on the light-matter interaction in a classic topological photonic crystal (PC) heterostructure, which consists of two opposite-facing 5-period PCs separated by a microfluidic channel. Becau MoreIn this paper, we introduce and analytically demonstrate a novel biosensor based on the light-matter interaction in a classic topological photonic crystal (PC) heterostructure, which consists of two opposite-facing 5-period PCs separated by a microfluidic channel. Because of the excitation of topological edge mode (TEM) at the interface of the two PCs, the strong coupling between incident light and TEM produces a high-quality resonance peak, which can be used to detect very small changes in the refractive index of biomaterials such as Jurkat Cells inside the microfluidic channel. The proposed biosensor has a sensitivity as high as 240 nm/RIU and figure of merit (FOM) higher than 250. Manuscript profile -
Open Access Article
7 - Fluence and wavelength optimization of pulsed laser in photothermal therapy
Rasoul Malekfar Neda AmjadiIssue 2 , Vol. 3 , Autumn 2024The ability of Plasmonic nanoparticles (PNPs) to efficiently convert absorbed light energy into localized heat has made them a popular choice for photothermal medical applications. However, during the photothermal process, the diffusion of localized heat can lead to tem MoreThe ability of Plasmonic nanoparticles (PNPs) to efficiently convert absorbed light energy into localized heat has made them a popular choice for photothermal medical applications. However, during the photothermal process, the diffusion of localized heat can lead to temperature management challenges. To address this issue, researchers have developed a new generation of PNPs incorporating optical phase transition materials, allowing for tunable photothermal responses without altering the geometry. This tunability is achieved through rapid changes in optical and thermal properties during phase transitions. In this study, we conducted a numerical analysis on the photothermal response of a VO2@Au smart nanoshell in both tumor and healthy liver tissue under irradiation with a nanosecond (5 ns) pulsed laser. To obtain the temperature profile, we solved a coupling problem between electromagnetism and thermodynamics. Manuscript profile -
Open Access Article
8 - Investigation of skin toxicity in breast cancer patients undergoing radiation therapy
Mohammad Bayatzadeh Sharifeh ShahiIssue 2 , Vol. 3 , Autumn 2024This study investigated skin toxicity in breast cancer patients undergoing radiation therapy. The study was conducted in 1401 at a radiation therapy center in Yazd city and included 30 patients who underwent radiation therapy using conventional and hypofractionation met MoreThis study investigated skin toxicity in breast cancer patients undergoing radiation therapy. The study was conducted in 1401 at a radiation therapy center in Yazd city and included 30 patients who underwent radiation therapy using conventional and hypofractionation methods, and in which the whole or part of the breast was exposed to radiation. Skin complications of grade skin toxicity during treatment and within 40 days after radiotherapy were evaluated in both methods. Results showed that the four people (26.6%) had grade three and the six people (40.0%) had grade two skin toxicity, with conventional treatment causing more skin complications compared to hypofractionation, which caused fewer skin complications without reducing efficacy. Additionally, the ratio of skin complications in the conventional technique was higher than in the hypofractionation technique after 40 days of radiation therapy. The study concluded that hypofractionation results in fewer skin complications than conventional treatment. Manuscript profile -
Open Access Article
9 - Effect of Protein Corona Formation on Photonic Response of Upconverting Nanoparticles
Nahid Ghazyani Mohammad Hossien Majles AraIssue 1 , Vol. 3 , Winter 2023NaYF4:Yb,Er is one of the efficient and well-known upconverting materials which emit photoluminescence light at 545 nm and 660 nm under an excitation of 980 nm. In this study, up-conversion nanoparticles using thermal decomposition method have been synthesized and chara MoreNaYF4:Yb,Er is one of the efficient and well-known upconverting materials which emit photoluminescence light at 545 nm and 660 nm under an excitation of 980 nm. In this study, up-conversion nanoparticles using thermal decomposition method have been synthesized and characterized and phase transition from organic to aquas by synthesis a SiO2 shell have done successfully. The results show that the nonlinearity response of NaYF4: Yb, Er@SiO2 is same as NaYF4: Yb, Er and SiO2 has no effect on emission peaks it means that these nanoparticles are suitable for biomedical applications. Since it is necessary to know the photoluminescent behavior of UCNPs@SiO2 particles, thereby the fluorescence properties of up-conversion nanoparticles with SiO2 shell have been investigated in PBS, normal and cancerous human blood plasma. The results indicate that UCNP@SiO2 can be applicable in biological medias for therapy and diagnostic. Manuscript profile -
Open Access Article
10 - Reduced Biofilm Formation of Pseudomonas Aeruginosa by Silver Modified Iron Oxide
Davoud kabudanian Raheleh Safaei javan Shohreh Zare kariziIssue 2 , Vol. 3 , Autumn 2024Objectives and Background: Pseudomonas aeruginosa (P. aeruginosa) is a nosocomial opportunistic pathogen. Considering the importance of biofilm in pathogenicity and resistance of these bacteria, efforts should be made to find new antibacterial compounds.Methods: The Fe3 MoreObjectives and Background: Pseudomonas aeruginosa (P. aeruginosa) is a nosocomial opportunistic pathogen. Considering the importance of biofilm in pathogenicity and resistance of these bacteria, efforts should be made to find new antibacterial compounds.Methods: The Fe3O4 nanoparticles were synthesized by the co-precipitation method and were modified by the AgNO3 reductive solution to investigate influencing of Ag-Fe3O4 nanoparticles on biofilm formation of P. aeruginosa. The synthesized nanoparticles properties were determined by FESEM, DLS, FTIR, XRD and Zeta potential tests. Results: FESEM and DLS revealed the cubic and smooth structure with average size of 44.36 nm. XRD analyzes confirmed the presence of magnetite core. FTIR spectrum determined the existence of silver plating on the magnetic surface. The Zeta potential results indicated that the magnetic nanoparticle’s surface net charge was 24.4 and the surface net charge for silver modified nanoparticles was -28.3. Finally, after separating 40 isolates of P. aeruginosa among 82 clinical isolates as strong biofilm producers, then the inhibitory effect of synthesised Ag- Fe3O4 nanoparticles on the formation of biofilms was studied using the broth micro-dilution method.Conclusions: Accordingly, it was proved that Ag-Fe3O4 nanoparticles can be used to treat biofilm infections and were introduced as the new antimicrobial agents Manuscript profile
